Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

Topoisomerase II (TOP2) relieves torsional stress by forming transient cleavage complex intermediates (TOP2ccs) that contain TOP2-linked DNA breaks (DSBs). While TOP2ccs are normally reversible, they can be “trapped” by chemotherapeutic drugs such as etoposide and subsequently converted into irrever...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Canela, Andres, Maman, Yaakov, Huang, Shar-yin N., Wutz, Gordana, Tang, Wen, Zagnoli-Vieira, Guido, Callen, Elsa, Wong, Nancy, Day, Amanda, Peters, Jan-Michael, Caldecott, Keith W., Pommier, Yves, Nussenzweig, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170508/
https://ncbi.nlm.nih.gov/pubmed/31202577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.04.030
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