TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome instability and chromosome translocation. TOP2-induced DNA double-strand breaks are rejoined in part by tyrosyl-DNA phosphodiesterase 2 (TDP2)-dependent non-homologous end-joining (N...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Gómez-Herreros, Fernando, Zagnoli-Vieira, Guido, Ntai, Ioanna, Martínez-Macías, María Isabel, Anderson, Rhona M., Herrero-Ruíz, Andrés, Caldecott, Keith W.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550487/
https://ncbi.nlm.nih.gov/pubmed/28794467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00307-y
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