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Substituted pyrazolones require N(2) hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal neurodegenerative disease. Although the cause remains unknown, misfolded protein aggregates are seen in neurons of sporadic ALS patients, and familial ALS mutations, including mutations in superoxide dismutase 1 (SOD1), produce proteins...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8168521/ https://ncbi.nlm.nih.gov/pubmed/23021992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.08.114 |
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