HGG-31. HISTONE H3.3 G34R/V MUTATIONS STIMULATE PEDIATRIC HIGH-GRADE GLIOMA FORMATION THROUGH THE INDUCTION OF CHROMOSOMAL INSTABILITY

The histone H3.3 G34R/V mutations are known drivers of high-grade pediatric glioma (pHGG). However, the mechanism(s) for H3.3 G34R/V induced tumor formation are unclear. Chk1 phosphorylates H3.3 S31 at the pericentromere during early mitosis, suggesting a novel mitotic function. We observed that H3....

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Grigore, Florina, Robinson, James, Langfald, Alyssa, Hinchcliffe, Edward, Day, Charles
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2021
Ämnen:
High Grade Gliomas
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168190/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.095
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