Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase

Human fatty acid synthase (FASN) is the sole cytosolic enzyme responsible for de novo lipid synthesis. FASN is essential for cancer cell survival and contributes to drug and radiation resistance by up-regulating DNA damage repair but not required for most non-lipogenic tissues. Thus, FASN is an attr...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Lett
Auteurs principaux: Wang, Chao J., Li, Deren, Danielson, Jacob A., Zhang, Evan H., Dong, Zizheng, Miller, Kathy D., Li, Lang, Zhang, Jian-Ting, Liu, Jing-Yuan
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167934/
https://ncbi.nlm.nih.gov/pubmed/33813001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2021.03.026
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