Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase

Human fatty acid synthase (FASN) is the sole cytosolic enzyme responsible for de novo lipid synthesis. FASN is essential for cancer cell survival and contributes to drug and radiation resistance by up-regulating DNA damage repair but not required for most non-lipogenic tissues. Thus, FASN is an attr...

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Udgivet i:Cancer Lett
Main Authors: Wang, Chao J., Li, Deren, Danielson, Jacob A., Zhang, Evan H., Dong, Zizheng, Miller, Kathy D., Li, Lang, Zhang, Jian-Ting, Liu, Jing-Yuan
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167934/
https://ncbi.nlm.nih.gov/pubmed/33813001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2021.03.026
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