Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

BACKGROUND & AIMS: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication str...

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Vydáno v:Gastroenterology
Hlavní autoři: Dreyer, Stephan B., Upstill-Goddard, Rosie, Paulus-Hock, Viola, Paris, Clara, Lampraki, Eirini-Maria, Dray, Eloise, Serrels, Bryan, Caligiuri, Giuseppina, Rebus, Selma, Plenker, Dennis, Galluzzo, Zachary, Brunton, Holly, Cunningham, Richard, Tesson, Mathias, Nourse, Craig, Bailey, Ulla-Maja, Jones, Marc, Moran-Jones, Kim, Wright, Derek W., Duthie, Fraser, Oien, Karin, Evers, Lisa, McKay, Colin J., McGregor, Grant A., Gulati, Aditi, Brough, Rachel, Bajrami, Ilirjana, Pettitt, Stephan, Dziubinski, Michele L., Candido, Juliana, Balkwill, Frances, Barry, Simon T., Grützmann, Robert, Rahib, Lola, Johns, Amber, Pajic, Marina, Froeling, Fieke E.M., Beer, Phillip, Musgrove, Elizabeth A., Petersen, Gloria M., Ashworth, Alan, Frame, Margaret C., Crawford, Howard C., Simeone, Diane M., Lord, Chris, Mukhopadhyay, Debabrata, Pilarsky, Christian, Tuveson, David A., Cooke, Susanna L., Jamieson, Nigel B., Morton, Jennifer P., Sansom, Owen J., Bailey, Peter J., Biankin, Andrew V., Chang, David K.
Médium: Artigo
Jazyk:Inglês
Vydáno: W.B. Saunders 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167930/
https://ncbi.nlm.nih.gov/pubmed/33039466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.09.043
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