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Restraining CDK1–cyclin B activation: PP2A on the cUSP(7)

USP7 inhibitors are gaining momentum as a therapeutic strategy to stabilize p53 through their ability to induce MDM2 degradation. However, these inhibitors come with an unexpected p53‐independent toxicity, via an unknown mechanism. In this issue of The EMBO Journal, Galarreta et al report how inhibi...

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Vydáno v:EMBO J
Hlavní autoři: Chow‐Castro, Marilynn, Dixon, Shandee D, Saldivar, Joshua C
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167361/
https://ncbi.nlm.nih.gov/pubmed/33969907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2021108486
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