Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy

The emergence of polymyxin resistance in Gram-negative bacteria infections has motivated the use of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B alone and in combination with meropenem and fosfomycin against A. baumannii strains belonging to clonal line...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fedrigo, Nayara Helisandra, Shinohara, Danielle Rosani, Mazucheli, Josmar, Nishiyama, Sheila Alexandra Belini, Carrara-Marroni, Floristher Elaine, Martins, Frederico Severino, Zhu, Peijuan, Yu, Mingming, Sy, Sherwin Kenneth B., Tognim, Maria Cristina Bronharo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167102/
https://ncbi.nlm.nih.gov/pubmed/34059725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90709-2
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