The differential solvent exposure of N-terminal residues provides “fingerprints” of alpha-synuclein fibrillar polymorphs

Synucleinopathies are neurodegenerative diseases characterized by the presence of intracellular deposits containing the protein alpha-synuclein (aSYN) within patients’ brains. It has been shown that aSYN can form structurally distinct fibrillar assemblies, also termed polymorphs. We previously showe...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Landureau, Maud, Redeker, Virginie, Bellande, Tracy, Eyquem, Stéphanie, Melki, Ronald
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163981/
https://ncbi.nlm.nih.gov/pubmed/33933456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100737
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