SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity

The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies. We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of heme metabolism, with nanomolar affinity. Using cryo–electron microscopy and x-ray crystallography, we mapped the...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Rosa, Annachiara, Pye, Valerie E., Graham, Carl, Muir, Luke, Seow, Jeffrey, Ng, Kevin W., Cook, Nicola J., Rees-Spear, Chloe, Parker, Eleanor, dos Santos, Mariana Silva, Rosadas, Carolina, Susana, Alberto, Rhys, Hefin, Nans, Andrea, Masino, Laura, Roustan, Chloe, Christodoulou, Evangelos, Ulferts, Rachel, Wrobel, Antoni G., Short, Charlotte-Eve, Fertleman, Michael, Sanders, Rogier W., Heaney, Judith, Spyer, Moira, Kjær, Svend, Riddell, Andy, Malim, Michael H., Beale, Rupert, MacRae, James I., Taylor, Graham P., Nastouli, Eleni, van Gils, Marit J., Rosenthal, Peter B., Pizzato, Massimo, McClure, Myra O., Tedder, Richard S., Kassiotis, George, McCoy, Laura E., Doores, Katie J., Cherepanov, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163077/
https://ncbi.nlm.nih.gov/pubmed/33888467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg7607
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