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SARS-CoV-2 recruits a haem metabolite to evade antibody immunity

The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies. We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity. Using cryo-electron microscopy and X-ray crystallography we mapped the t...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রকাশিত:medRxiv
প্রধান লেখক: Rosa, Annachiara, Pye, Valerie E., Graham, Carl, Muir, Luke, Seow, Jeffrey, Ng, Kevin W., Cook, Nicola J., Rees-Spear, Chloe, Parker, Eleanor, dos Santos, Mariana Silva, Rosadas, Carolina, Susana, Alberto, Rhys, Hefin, Nans, Andrea, Masino, Laura, Roustan, Chloe, Christodoulou, Evangelos, Ulferts, Rachel, Wrobel, Antoni, Short, Charlotte-Eve, Fertleman, Michael, Sanders, Rogier W., Heaney, Judith, Spyer, Moira, Kjær, Svend, Riddell, Andy, Malim, Michael H., Beale, Rupert, MacRae, James I., Taylor, Graham P., Nastouli, Eleni, van Gils, Marit J., Rosenthal, Peter B., Pizzato, Massimo, McClure, Myra O., Tedder, Richard S., Kassiotis, George, McCoy, Laura E., Doores, Katie J., Cherepanov, Peter
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: Cold Spring Harbor Laboratory 2021
বিষয়গুলি:
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852234/
https://ncbi.nlm.nih.gov/pubmed/33532784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.21.21249203
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