SARS-CoV-2 recruits a haem metabolite to evade antibody immunity

The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies. We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity. Using cryo-electron microscopy and X-ray crystallography we mapped the t...

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Pubblicato in:medRxiv
Autori principali: Rosa, Annachiara, Pye, Valerie E., Graham, Carl, Muir, Luke, Seow, Jeffrey, Ng, Kevin W., Cook, Nicola J., Rees-Spear, Chloe, Parker, Eleanor, dos Santos, Mariana Silva, Rosadas, Carolina, Susana, Alberto, Rhys, Hefin, Nans, Andrea, Masino, Laura, Roustan, Chloe, Christodoulou, Evangelos, Ulferts, Rachel, Wrobel, Antoni, Short, Charlotte-Eve, Fertleman, Michael, Sanders, Rogier W., Heaney, Judith, Spyer, Moira, Kjær, Svend, Riddell, Andy, Malim, Michael H., Beale, Rupert, MacRae, James I., Taylor, Graham P., Nastouli, Eleni, van Gils, Marit J., Rosenthal, Peter B., Pizzato, Massimo, McClure, Myra O., Tedder, Richard S., Kassiotis, George, McCoy, Laura E., Doores, Katie J., Cherepanov, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852234/
https://ncbi.nlm.nih.gov/pubmed/33532784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.21.21249203
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