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Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism

Nicotine addiction is a worldwide epidemic that claims millions of lives each year. Genetic deletion of α5 nicotinic acetylcholine receptor (nAChR) subunits has been associated with increased nicotine intake, however, it remains unclear whether acute nicotine is less aversive or more rewarding, and...

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Publicado en:Eur J Neurosci
Autores principales: Grieder, Taryn E., George, Olivier, Yee, Mandy, Bergamini, Michael A., Chwalek, Michal, Maal-Bared, Geith, Vargas-Perez, Hector, van der Kooy, Derek
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162765/
https://ncbi.nlm.nih.gov/pubmed/28498560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.13605
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