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Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism

Nicotine addiction is a worldwide epidemic that claims millions of lives each year. Genetic deletion of α5 nicotinic acetylcholine receptor (nAChR) subunits has been associated with increased nicotine intake, however, it remains unclear whether acute nicotine is less aversive or more rewarding, and...

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Bibliografiset tiedot
Julkaisussa:Eur J Neurosci
Päätekijät: Grieder, Taryn E., George, Olivier, Yee, Mandy, Bergamini, Michael A., Chwalek, Michal, Maal-Bared, Geith, Vargas-Perez, Hector, van der Kooy, Derek
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162765/
https://ncbi.nlm.nih.gov/pubmed/28498560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.13605
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