Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal

Nicotine, the main psychoactive ingredient of tobacco smoke, induces negative motivational symptoms during withdrawal that contribute to relapse in dependent individuals. The neurobiological mechanisms underlying how the brain signals nicotine withdrawal remain poorly understood. Using electrophysio...

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Detalles Bibliográficos
Autores principales: Grieder, Taryn E., George, Olivier, Tan, Huibing, George, Susan R., Le Foll, Bernard, Laviolette, Steven R., van der Kooy, Derek
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286981/
https://ncbi.nlm.nih.gov/pubmed/22308372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114422109
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