Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal

Nicotine, the main psychoactive ingredient of tobacco smoke, induces negative motivational symptoms during withdrawal that contribute to relapse in dependent individuals. The neurobiological mechanisms underlying how the brain signals nicotine withdrawal remain poorly understood. Using electrophysio...

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Detalhes bibliográficos
Main Authors: Grieder, Taryn E., George, Olivier, Tan, Huibing, George, Susan R., Le Foll, Bernard, Laviolette, Steven R., van der Kooy, Derek
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286981/
https://ncbi.nlm.nih.gov/pubmed/22308372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114422109
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