Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment, and disease

Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA and surface protein data from 500,089 memory T cells to define 31 cell states from 259 individuals in a Peruvian tuberculosis (TB) progression cohort. A...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Nathan, Aparna, Beynor, Jessica I., Baglaenko, Yuriy, Suliman, Sara, Ishigaki, Kazuyoshi, Asgari, Samira, Huang, Chuan-Chin, Luo, Yang, Zhang, Zibiao, Lopez, Kattya, Arlehamn, Cecilia S. Lindestam, Ernst, Joel D., Jimenez, Judith, Calderón, Roger I., Lecca, Leonid, Van Rhijn, Ildiko, Moody, D. Branch, Murray, Megan B., Raychaudhuri, Soumya
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162307/
https://ncbi.nlm.nih.gov/pubmed/34031617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00933-1
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