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Is it time for biocatalysis in fragment-based drug discovery?

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment...

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Vydáno v:Chem Sci
Hlavní autoři: Ramsden, Jeremy I., Cosgrove, Sebastian C., Turner, Nicholas J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162304/
https://ncbi.nlm.nih.gov/pubmed/34094353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc04103c
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