Peptide late-stage C(sp(3))–H arylation by native asparagine assistance without exogenous directing groups

There is a strong demand for novel native peptide motifs for post-synthetic modifications of peptides without pre-installation and subsequent removal of directing groups. Herein, we report an efficient method for peptide late-stage C(sp(3))–H arylations assisted by the unmodified side chain of aspar...

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Udgivet i:Chem Sci
Main Authors: Weng, Yiyi, Ding, Xingxing, Oliveira, João C. A., Xu, Xiaobin, Kaplaneris, Nikolaos, Zhu, Meijie, Chen, Hantao, Chen, Zhuo, Ackermann, Lutz
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2020
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161531/
https://ncbi.nlm.nih.gov/pubmed/34094199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc03830j
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