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Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
Methods for the late-stage diversification of structurally complex peptides hold enormous potential for advances in drug discovery, agrochemistry and pharmaceutical industries. While C–H arylations emerged for peptide modifications, they are largely limited to highly reactive, expensive and/or toxic...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6685959/ https://ncbi.nlm.nih.gov/pubmed/31391461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11395-3 |
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