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Design, Synthesis, and Evaluation of Dihydropyranopyrazole Derivatives as Novel PDE2 Inhibitors for the Treatment of Alzheimer’s Disease
Phosphodiesterase 2 (PDE2) has been regarded as a novel target for the treatment of Alzheimer’s disease (AD). In this study, we obtained (R)-LZ77 as a hit compound with moderate PDE2 inhibitory activity (IC(50) = 261.3 nM) using a high-throughput virtual screening method based on molecular dynamics....
Guardat en:
| Publicat a: | Molecules |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8160813/ https://ncbi.nlm.nih.gov/pubmed/34069639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26103034 |
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