Design, Synthesis, and Evaluation of Dihydropyranopyrazole Derivatives as Novel PDE2 Inhibitors for the Treatment of Alzheimer’s Disease

Phosphodiesterase 2 (PDE2) has been regarded as a novel target for the treatment of Alzheimer’s disease (AD). In this study, we obtained (R)-LZ77 as a hit compound with moderate PDE2 inhibitory activity (IC(50) = 261.3 nM) using a high-throughput virtual screening method based on molecular dynamics....

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Publicado no:Molecules
Main Authors: Zhou, Yan, Li, Jinjian, Yuan, Han, Su, Rui, Huang, Yue, Huang, Yiyou, Li, Zhe, Wu, Yinuo, Luo, Haibin, Zhang, Chen, Huang, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160813/
https://ncbi.nlm.nih.gov/pubmed/34069639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26103034
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