DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A

Oncogene-induced senescence (OIS) is a stable cell cycle arrest that occurs in normal cells upon oncogene activation. Cells undergoing OIS express a wide variety of secreted factors that affect the senescent microenvironment termed the senescence-associated secretory phenotype (SASP), which is benef...

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Publié dans:J Cell Biol
Auteurs principaux: Leon, Kelly E., Buj, Raquel, Lesko, Elizabeth, Dahl, Erika S., Chen, Chi-Wei, Tangudu, Naveen Kumar, Imamura-Kawasawa, Yuka, Kossenkov, Andrew V., Hobbs, Ryan P., Aird, Katherine M.
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2021
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160577/
https://ncbi.nlm.nih.gov/pubmed/34037658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202008101
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