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Targeting IDH1 as a pro-senescent therapy in high-grade serous ovarian cancer

Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer. High-grade serous carcinoma (HGSC) is the most frequently diagnosed and lethal histosubtype of EOC. A significant proportion of HGSC patients relapse with chemoresistant disease. Therefore, there is an urgent need for novel thera...

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Publicat a:Mol Cancer Res
Autors principals: Dahl, Erika S., Buj, Raquel, Leon, Kelly E., Newell, Jordan M., Imamura, Yuka, Bitler, Benjamin G., Snyder, Nathaniel W., Aird, Katherine M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679739/
https://ncbi.nlm.nih.gov/pubmed/31110157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1233
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