Modular network mechanism of CCN1-associated resistance to HSV-1-derived oncolytic immunovirotherapies for glioblastomas

Glioblastomas (GBMs) are the most common and lethal primary brain malignancy in adults. Oncolytic virus (OV) immunotherapies selectively kill GBM cells in a manner that elicits antitumor immunity. Cellular communication network factor 1 (CCN1), a protein found in most GBM microenvironments, expressi...

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Udgivet i:Sci Rep
Main Authors: Monie, Dileep D., Correia, Cristina, Zhang, Cheng, Ung, Choong Yong, Vile, Richard G., Li, Hu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159930/
https://ncbi.nlm.nih.gov/pubmed/34045642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90718-1
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