EPCT-22 SAFETY AND EFFICACY OF INTRAVENTRICULAR IMMUNOVIROTHERAPY WITH ONCOLYTIC HSV-1 G207 FOR TREATMENT OF LEPTOMENINGEAL DISEASE

Leptomeningeal metastatic disease (LMD) occurs in 30–50% of newly diagnosed and recurrent pediatric malignant cerebellar tumors and 20–45% of malignant supratentorial tumors. Radiation and chemotherapy often cause substantial long-term neurotoxicity and outcomes remain poor for patients with LMD. At...

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發表在:Neuro Oncol
Main Authors: Kang, Kyung-Don, Bernstock, Joshua, Mott, Bryan, Nan, Li, Li, Rong, Totsch, Stacie, Gary, Sam, Ghajar-Rahimi, Gelare, Etminan, Tina, Eisemann, Tanja, Wechsler-Reya, Robert, Beierle, Elizabeth, Gillespie, George, Markert, James, Friedman, Gregory
格式: Artigo
語言:Inglês
出版: Oxford University Press 2021
主題:
Translational/Early Phase Clinical Trials
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168116/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.208
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