NAD(+) Repletion Reverses Heart Failure with Preserved Ejection Fraction

RATIONALE: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without effective therapies. We recently demonstrated in mice that a combination of metabolic and hypertensive stress recapitulates key features of human HFpEF. OBJECTIVE: Using this novel preclinical HFp...

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Vydáno v:Circ Res
Hlavní autoři: Tong, Dan, Schiattarella, Gabriele G., Jiang, Nan, Altamirano, Francisco, Szweda, Pamela A., Elnwasany, Abdallah, Lee, Dong Ik, Yoo, Heesoo, Kass, David A., Szweda, Luke I., Lavandero, Sergio, Verdin, Eric, Gillette, Thomas G., Hill, Joseph A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159891/
https://ncbi.nlm.nih.gov/pubmed/33882692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.317046
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