The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens

INTRODUCTION: The prevalence of 2R/2R TYMS genotype is variable but estimated to be around 20–30% in Caucasians. The clinical relevance of TYMS 2R/2R genotype in predicting severe fluoropyrimidine-related adverse events (FrAE) is controversial. Here, we explored the prevalence and clinical relevance...

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Detalhes bibliográficos
Publicado no:Pharmacogenomics J
Main Authors: Khushman, Moh’d, Patel, Girijesh Kumar, Maharjan, Anu Singh, McMillin, Gwendolyn A., Nelson, Cindy, Hosein, Peter, Singh, Ajay P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159739/
https://ncbi.nlm.nih.gov/pubmed/33608662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-021-00210-2
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