Germline pharmacogenomics of DPYD*9A (c.85T>C) variant in patients with gastrointestinal malignancies treated with fluoropyrimidines

BACKGROUND: The correlation between DPYD*9A (c.85T>C) genotype and dihydropyrimidine dehydrogenase (DPD) deficiency clinical phenotype is controversial. Reference laboratories either did not perform DPYD*9A genotyping or have stopped DPYD*9A genotyping and limited genotyping to high-risk variants...

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Detalhes bibliográficos
Publicado no:J Gastrointest Oncol
Main Authors: Khushman, Moh’d, Patel, Girijesh Kumar, Hosein, Peter Joel, Laurini, Javier Ariel, Cameron, Daniel, Clarkson, David Roland, Butler, Thomas Wayne, Norden, Carole Wiseman, Baliem, Wilma, Jones, Vanessa, Bhadkamkar, Sanjyot, Nelson, Cindy, Lee, Frances, Singh, Ajay P., Taylor, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006041/
https://ncbi.nlm.nih.gov/pubmed/29998006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jgo.2018.02.03
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