Germline pharmacogenomics of DPYD*9A (c.85T>C) variant in patients with gastrointestinal malignancies treated with fluoropyrimidines

BACKGROUND: The correlation between DPYD*9A (c.85T>C) genotype and dihydropyrimidine dehydrogenase (DPD) deficiency clinical phenotype is controversial. Reference laboratories either did not perform DPYD*9A genotyping or have stopped DPYD*9A genotyping and limited genotyping to high-risk variants...

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Bibliografske podrobnosti
izdano v:J Gastrointest Oncol
Main Authors: Khushman, Moh’d, Patel, Girijesh Kumar, Hosein, Peter Joel, Laurini, Javier Ariel, Cameron, Daniel, Clarkson, David Roland, Butler, Thomas Wayne, Norden, Carole Wiseman, Baliem, Wilma, Jones, Vanessa, Bhadkamkar, Sanjyot, Nelson, Cindy, Lee, Frances, Singh, Ajay P., Taylor, William R.
Format: Artigo
Jezik:Inglês
Izdano: AME Publishing Company 2018
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006041/
https://ncbi.nlm.nih.gov/pubmed/29998006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jgo.2018.02.03
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