Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK

BACKGROUND: Chemoresistance is a significant clinical problem in pancreatic cancer (PC) and underlying molecular mechanisms still remain to be completely understood. Here we report a novel exosome-mediated mechanism of drug-induced acquired chemoresistance in PC cells. METHODS: Differential ultracen...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Patel, Girijesh Kumar, Khan, Mohammad Aslam, Bhardwaj, Arun, Srivastava, Sanjeev K, Zubair, Haseeb, Patton, Mary C, Singh, Seema, Khushman, Moh'd, Singh, Ajay P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344296/
https://ncbi.nlm.nih.gov/pubmed/28152544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.18
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados