Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK

BACKGROUND: Chemoresistance is a significant clinical problem in pancreatic cancer (PC) and underlying molecular mechanisms still remain to be completely understood. Here we report a novel exosome-mediated mechanism of drug-induced acquired chemoresistance in PC cells. METHODS: Differential ultracen...

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Bibliografske podrobnosti
izdano v:Br J Cancer
Main Authors: Patel, Girijesh Kumar, Khan, Mohammad Aslam, Bhardwaj, Arun, Srivastava, Sanjeev K, Zubair, Haseeb, Patton, Mary C, Singh, Seema, Khushman, Moh'd, Singh, Ajay P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344296/
https://ncbi.nlm.nih.gov/pubmed/28152544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.18
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