Glucose deprivation–induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma

Rapidly growing tumors often experience hypoxia and nutrient (e.g., glucose) deficiency because of poor vascularization. Tumor cells respond to the cytotoxic effects of such stresses by inducing molecular adaptations that promote clonal selection of a more malignant tumor-initiating cell phenotype,...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Loong, Jane H.C., Wong, Tin-Lok, Tong, Man, Sharma, Rakesh, Zhou, Lei, Ng, Kai-Yu, Yu, Hua-Jian, Li, Chi-Han, Man, Kwan, Lo, Chung-Mau, Guan, Xin-Yuan, Lee, Terence K., Yun, Jing-Ping, Ma, Stephanie K.Y.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159685/
https://ncbi.nlm.nih.gov/pubmed/33878034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143377
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