Glucose deprivation–induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma

Rapidly growing tumors often experience hypoxia and nutrient (e.g., glucose) deficiency because of poor vascularization. Tumor cells respond to the cytotoxic effects of such stresses by inducing molecular adaptations that promote clonal selection of a more malignant tumor-initiating cell phenotype,...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Loong, Jane H.C., Wong, Tin-Lok, Tong, Man, Sharma, Rakesh, Zhou, Lei, Ng, Kai-Yu, Yu, Hua-Jian, Li, Chi-Han, Man, Kwan, Lo, Chung-Mau, Guan, Xin-Yuan, Lee, Terence K., Yun, Jing-Ping, Ma, Stephanie K.Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159685/
https://ncbi.nlm.nih.gov/pubmed/33878034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143377
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