Chemotherapy‐Enriched THBS2‐Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

The physical microenvironment is a critical mediator of tumor behavior. However, detailed biological and mechanistic insight is lacking. The present study reveals the role of chemotherapy‐enriched CD133+ liver cancer stem cells (CSCs) with THBS2 deficiency. This subpopulation of cells contributes to...

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Bibliographic Details
Published in:Adv Sci (Weinh)
Main Authors: Ng, Kai‐Yu, Shea, Queenie T., Wong, Tin‐Lok, Luk, Steve T., Tong, Man, Lo, Chung‐Mau, Man, Kwan, Yun, Jing‐Ping, Guan, Xin‐Yuan, Lee, Terence K., Zheng, Yong‐Ping, Ma, Stephanie
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927606/
https://ncbi.nlm.nih.gov/pubmed/33717837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.202002483
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