“CLipP”ing on lipids to generate antibacterial lipopeptides

We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel “CLipP”ed lipopeptides exhibited low micromolar MICs and MBCs agai...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Yim, Victor, Kavianinia, Iman, Knottenbelt, Melanie K., Ferguson, Scott A., Cook, Gregory M., Swift, Simon, Chakraborty, Aparajita, Allison, Jane R., Cameron, Alan J., Harris, Paul W. R., Brimble, Margaret A.
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society of Chemistry 2020
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159387/
https://ncbi.nlm.nih.gov/pubmed/34094080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc01814g
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