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“CLipP”ing on lipids to generate antibacterial lipopeptides
We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel “CLipP”ed lipopeptides exhibited low micromolar MICs and MBCs agai...
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| 發表在: | Chem Sci |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Royal Society of Chemistry
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8159387/ https://ncbi.nlm.nih.gov/pubmed/34094080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc01814g |
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