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Thiol-ene Enabled Chemical Synthesis of Truncated S-Lipidated Teixobactin Analogs
Herein is described the introduction of lipid moieties onto a simplified teixobactin pharmacophore using a modified Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technique, whereby cysteine was substituted for 3-mercaptopropionic acid (3-MPA). A truncated teixobactin analog was prepared wi...
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| Pubblicato in: | Front Chem |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7417771/ https://ncbi.nlm.nih.gov/pubmed/32850619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00568 |
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