Thiol-ene Enabled Chemical Synthesis of Truncated S-Lipidated Teixobactin Analogs

Herein is described the introduction of lipid moieties onto a simplified teixobactin pharmacophore using a modified Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technique, whereby cysteine was substituted for 3-mercaptopropionic acid (3-MPA). A truncated teixobactin analog was prepared wi...

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Dades bibliogràfiques
Publicat a:Front Chem
Autors principals: Yim, Victor V., Cameron, Alan J., Kavianinia, Iman, Harris, Paul W. R., Brimble, Margaret A.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7417771/
https://ncbi.nlm.nih.gov/pubmed/32850619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00568
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