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Real-World Use of Azathioprine Metabolites Changes Clinical Management of Inflammatory Bowel Disease

BACKGROUND: Thiopurines such as 6-mercaptopurine and azathioprine have complex metabolism, resulting in significant inter-individual differences in clinical efficacy and risk of drug toxicity, making conventional weight-based dosing inaccurate and potentially unsafe. Therapeutic drug monitoring (TDM...

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Bibliografiske detaljer
Udgivet i:J Can Assoc Gastroenterol
Main Authors: Wilson, Laura, Tuson, Stephanie, Yang, Lufang, Loomes, Dustin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158651/
https://ncbi.nlm.nih.gov/pubmed/34056527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwaa005
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