Genetically edited CD34(+) cells derived from human iPS cells in vivo but not in vitro engraft and differentiate into HIV-resistant cells

Genetic editing of induced pluripotent stem (iPS) cells represents a promising avenue for an HIV cure. However, certain challenges remain before bringing this approach to the clinic. Among them, in vivo engraftment of cells genetically edited in vitro needs to be achieved. In this study, CD34(+) cel...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Morvan, Maelig G., Teque, Fernando, Ye, Lin, Moreno, Mary E., Wang, Jiaming, VandenBerg, Scott, Stoddart, Cheryl A., Kan, Yuet Wai, Levy, Jay A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158014/
https://ncbi.nlm.nih.gov/pubmed/33975958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2102404118
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