Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding

Heterozygous point mutations of α-synuclein (α-syn) have been linked to the early onset and rapid progression of familial Parkinson’s diseases (fPD). However, the interplay between hereditary mutant and wild-type (WT) α-syn and its role in the exacerbated pathology of α-syn in fPD progression are po...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Long, Houfang, Zheng, Weitong, Liu, Yang, Sun, Yunpeng, Zhao, Kun, Liu, Zhenying, Xia, Wencheng, Lv, Shiran, Liu, Zhengtao, Li, Dan, He, Kai-Wen, Liu, Cong
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158012/
https://ncbi.nlm.nih.gov/pubmed/33972418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012435118
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