Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1

Malaria is a devastating infectious disease, which causes over 400,000 deaths per annum and impacts the lives of nearly half the world’s population. The causative agent, a protozoan parasite, replicates within red blood cells (RBCs), eventually destroying the cells in a lytic process called egress t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Lidumniece, Elina, Withers-Martinez, Chrislaine, Hackett, Fiona, Collins, Christine R., Perrin, Abigail J., Koussis, Konstantinos, Bisson, Claudine, Blackman, Michael J., Jirgensons, Aigars
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2021
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157947/
https://ncbi.nlm.nih.gov/pubmed/33975947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022696118
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