BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated G(q) activation at early endosomes

G protein–coupled receptors (GPCRs) are gatekeepers of cellular homeostasis and the targets of a large proportion of drugs. In addition to their signaling activity at the plasma membrane, it has been proposed that their actions may result from translocation and activation of G proteins at endomembra...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wright, Shane C., Lukasheva, Viktoriya, Le Gouill, Christian, Kobayashi, Hiroyuki, Breton, Billy, Mailhot-Larouche, Samuel, Blondel-Tepaz, Élodie, Antunes Vieira, Nichelle, Costa-Neto, Claudio, Héroux, Madeleine, Lambert, Nevin A., Parreiras-e-Silva, Lucas Tabajara, Bouvier, Michel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157916/
https://ncbi.nlm.nih.gov/pubmed/33990469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025846118
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