Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by motor deficits correlated with progressive dopaminergic neuronal loss in the substantia nigra pars compacta (SN). Necroptosis is a caspase-independent form of regulated cell death mediated by the c...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Oliveira, Sara R., Dionísio, Pedro A., Gaspar, Maria M., Ferreira, Maria B. T., Rodrigues, Catarina A. B., Pereira, Rita G., Estevão, Mónica S., Perry, Maria J., Moreira, Rui, Afonso, Carlos A. M., Amaral, Joana D., Rodrigues, Cecília M. P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157267/
https://ncbi.nlm.nih.gov/pubmed/34069782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105289
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