Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models

BACKGROUND & AIMS: Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or transport. Post-translational modifications (PTMs) are implicated in protei...

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Bibliografske podrobnosti
izdano v:J Hepatol
Main Authors: Lee-Law, Pui Y., Olaizola, Paula, Caballero-Camino, Francisco J., Izquierdo-Sanchez, Laura, Rodrigues, Pedro M., Santos-Laso, Alvaro, Azkargorta, Mikel, Elortza, Felix, Martinez-Chanta, Maria L., Perugorria, Maria J., Aspichueta, Patricia, Marzioni, Marco, LaRusso, Nicholas F., Bujanda, Luis, Drenth, Joost P.H., Banales, Jesus M.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157180/
https://ncbi.nlm.nih.gov/pubmed/32950589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2020.09.010
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