Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases

OBJECTIVE: Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix meta...

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Publicado no:Gut
Main Authors: Urribarri, Aura D, Munoz-Garrido, Patricia, Perugorria, María J, Erice, Oihane, Merino-Azpitarte, Maite, Arbelaiz, Ander, Lozano, Elisa, Hijona, Elizabeth, Jiménez-Agüero, Raúl, Fernandez-Barrena, Maite G, Jimeno, Juan P, Marzioni, Marco, Marin, Jose J G, Masyuk, Tatyana V, LaRusso, Nicholas F, Prieto, Jesús, Bujanda, Luis, Banales, Jesús M
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362729/
https://ncbi.nlm.nih.gov/pubmed/24436140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2013-305281
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