SOX17 Regulates Cholangiocyte Differentiation and Acts as a Tumor Suppressor in Cholangiocarcinoma

BACKGROUND & AIMS: Cholangiocarcinoma (CCA) is a biliary malignancy linked to genetic and epigenetic abnormalities, such as hypermethylation of SOX17 promoter. Here, the role of SOX17 in cholangiocyte differentiation and cholangiocarcinogenesis was studied. METHODS: SOX17 expression/function was...

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Publicado en:J Hepatol
Autores principales: Merino-Azpitarte, M, Lozano, E, Perugorria, MJ, Esparza-Baquer, A, Erice, O, Santos-Laso, A, O'Rourke, CJ, Andersen, JB, Jiménez-Agüero, R, Lacasta, A, D'Amato, M, Briz, O, Jalan-Sakrikar, N, Huebert, RC, Thelen, KM, Gradilone, SA, Aransay, AM, Lavín, JL, Fernández-Barrena, MG, Matheu, A, Marzioni, M, Gores, GJ, Bujanda, L, Marin, JJG, Banales, JM
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502751/
https://ncbi.nlm.nih.gov/pubmed/28237397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2017.02.017
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