Distinct Concentration-Dependent Molecular Pathways Regulate Bone Cell Responses to Cobalt and Chromium Exposure from Joint Replacement Prostheses

Systemic cobalt (Co) and chromium (Cr) concentrations may be elevated in patients with metal joint replacement prostheses. Several studies have highlighted the detrimental effects of this exposure on bone cells in vitro, but the underlying mechanisms remain unclear. In this study, we use whole-genom...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Shah, Karan M., Dunning, Mark J., Gartland, Alison, Wilkinson, J. Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156984/
https://ncbi.nlm.nih.gov/pubmed/34069294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105225
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