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Distinct Concentration-Dependent Molecular Pathways Regulate Bone Cell Responses to Cobalt and Chromium Exposure from Joint Replacement Prostheses

Systemic cobalt (Co) and chromium (Cr) concentrations may be elevated in patients with metal joint replacement prostheses. Several studies have highlighted the detrimental effects of this exposure on bone cells in vitro, but the underlying mechanisms remain unclear. In this study, we use whole-genom...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Shah, Karan M., Dunning, Mark J., Gartland, Alison, Wilkinson, J. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156984/
https://ncbi.nlm.nih.gov/pubmed/34069294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105225
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