Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and potent small-molecule inhibitor of Gal-3. A randomised, double-blind, multicentre, placebo-controlled, phase 1/2...

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Udgivet i:Eur Respir J
Main Authors: Hirani, Nikhil, MacKinnon, Alison C., Nicol, Lisa, Ford, Paul, Schambye, Hans, Pedersen, Anders, Nilsson, Ulf J., Leffler, Hakon, Sethi, Tariq, Tantawi, Susan, Gravelle, Lise, Slack, Robert J., Mills, Ross, Karmakar, Utsa, Humphries, Duncan, Zetterberg, Fredrik, Keeling, Lucy, Paul, Lyn, Molyneaux, Philip L., Li, Feng, Funston, Wendy, Forrest, Ian A., Simpson, A. John, Gibbons, Michael A., Maher, Toby M.
Format: Artigo
Sprog:Inglês
Udgivet: European Respiratory Society 2021
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156151/
https://ncbi.nlm.nih.gov/pubmed/33214209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02559-2020
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