Structure–Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors

[Image: see text] We identified nitazoxanide (NTZ) as a moderate STAT3 pathway inhibitor through immunoblot analysis and a cell-based IL-6/JAK/STAT3 pathway activation assay. A series of thiazolide derivatives were designed and synthesized to further validate the thiazolide scaffold as STAT3 inhibit...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Lü, Zirui, Li, Xiaona, Li, Kebin, Wang, Cong, Du, Tingting, Huang, Wei, Ji, Ming, Li, Changhong, Xu, Fengrong, Xu, Ping, Niu, Yan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2021
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155281/
https://ncbi.nlm.nih.gov/pubmed/34055214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00544
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