Discovery of a Potent and Selective Covalent p300/CBP Inhibitor

[Image: see text] Aberrant gene activation driven by the histone acetyltransferases p300 and CREB binding protein (CBP) has been linked to several diseases, including cancers. Because of this, many efforts have been aimed toward the targeting of the closely related paralogues, p300 and CBP, but thes...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Mastracchio, Anthony, Lai, Chunqiu, Digiammarino, Enrico, Ready, Damien B., Lasko, Loren M., Bromberg, Kenneth D., McClellan, William J., Montgomery, Debra, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Patterson, Melanie J., Sun, Chaohong C., Rosenberg, Saul, Lai, Albert, Michaelides, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155265/
https://ncbi.nlm.nih.gov/pubmed/34055218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00654
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